What is Amino LP7? Can It Really Keep Dementia at Bay?

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Researchers say an amino acid combination called Amino LP7 can hinder the development of dementia, including Alzheimer's disease. Learn more.

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Japanese researchers have found that an amino acid supplement can protect the brains of older people from dementia. The researchers found in a recent study published in Science Advances that a low protein diet can accelerate brain degeneration in mouse models of Alzheimer's disease.

The researchers also found that Amino LP7, the supplement containing Leucine, Phenylalanine, Lysine, Isoleucine, Histidine, Valine and Tryptophan, slowed down brain degeneration and dementia development in the mice. Their work expands on previous studies which have demonstrated the effectiveness of Amino LP7 in improving cognitive function.

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10 million new dementia sufferers per year

Dementia -- a condition involving the extreme loss of cognitive function -- is caused by a variety of disorders, including Alzheimer's disease.

According to World Health Organization estimates, approximately 10 million individuals worldwide develop dementia every year, indicating the high psychological and social impact of this condition. Dementia mainly affects older people, and so far, simple and effective strategies for preventing this condition have remained elusive.

Dr. Makoto Higuchi from the National Institutes for Quantum Sciences and Technology, one of the lead scientists on the study, explains, "In older individuals, low protein diets are linked to poor maintenance of brain function. Amino acids are the building blocks of proteins.

"We wanted to understand whether supplementation with essential amino acids can protect the brains of older people from dementia, and if yes, what mechanisms would contribute to this protective effect."

What they did

First, the researchers studied how a low protein diet affects the brain in mouse models of Alzheimer's disease, which generally demonstrate neurodegeneration and abnormal protein aggregates called "Tau" aggregates in the brain.

They found that mice consuming a low protein diet not only showed accelerated brain degeneration but also had signs of poor neuronal connectivity. Interestingly, these effects were reversed after supplementation with Amino LP7, indicating that the combination of seven specific amino acids could inhibit brain damage.

Next, the research team examined how Amino LP7 affects different signs of brain degeneration in the Alzheimer's model. Untreated mice showed high levels of progressive brain degeneration, but Amino LP7 treatment suppressed neuronal death and thereby reduced brain degeneration, even though the Tau aggregates remained.

What they found

According to Dr. Akihiko Kitamura, who also led this study, "Tau plaques in the brain are characteristic of Alzheimer's and most treatments target them. However, we have shown it is possible to overcome this Tau deposition and prevent brain atrophy via supplementation with Amino LP7."

Next, to understand how Amino LP7 protects the brain, the researchers comprehensively analyzed the gene-level changes induced by Amino LP7. Their findings were quite encouraging.

The researchers observed that Amino LP7 reduces brain inflammation and also prevents kynurenine, an inflammation inducer, from entering the brain, thereby preventing inflammatory immune cells from attacking neurons. They also found that Amino LP7 reduces neuronal death and improves neuronal connectivity, improving brain function.

Hope for the future

"These results suggest that essential amino acids can help maintain balance in the brain and prevent brain deterioration. Our study is the first to report that specific amino acids can hinder the development of dementia," say Dr. Hideaki Sato and Dr. Yuhei Takado, both of whom greatly contributed to the study.

"Although our study was performed in mice, it brings hope that amino acid intake could also modify the development of dementias in humans, including Alzheimer's disease," they add.

The study by this research group throws open several avenues for better understanding how dementias occur and how they can be prevented. Given that Amino LP7 (Leucine, Phenylalanine, Lysine, Isoleucine, Histidine, Valine and Tryptophan) improves brain function in older people without cognitive impairment, their findings suggest that it could also be effective in people with cognitive dysfunction.

SOURCE:

• The National Institutes for Quantum Science and Technology

REFERENCE:

• Hideaki Sato, Yuhei Takado, Sakiko Toyoda, Masako Tsukamoto-Yasui, Keiichiro Minatohara, Hiroyuki Takuwa, Takuya Urushihata, Manami Takahashi, Masafumi Shimojo, Maiko Ono, Jun Maeda, Asumi Orihara, Naruhiko Sahara, Ichio Aoki, Sachise Karakawa, Muneki Isokawa, Noriko Kawasaki, Mika Kawasaki, Satoko Ueno, Mayuka Kanda, Mai Nishimura, Katsuya Suzuki, Akira Mitsui, Kenji Nagao, Akihiko Kitamura, Makoto Higuchi. Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model. Science Advances, 2021; 7 (43) DOI: 10.1126/sciadv.abd5046