Alzheimer's Risk from Family History

GENETICS & LIFESTYLE VIDEO:

How do family history and genetics affect a healthy person's risk of Alzheimer's? Watch Harvard's Top Alzheimer's researcher, Dr. Rudy Tanzi, offer down-to-Earth insights.

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What is Epigenomics? How Does It Affect Alzheimer's?

Epigenomics enables us to nurture what our genes do through the way we live. Find out how MIT researchers are mastering epigenomics to beat Alzheimer's.

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How Alzheimer's Genes Jam Up Brain Cleanings by Immune Cells

Genes

PROGRESS NEWS: The most prevalent genetic risk factor of Alzheimer's is apolipoprotein E4 (APOE4). How does this gene do its damage? A new study reveals it impairs the function of brain immune cells called microglia. Learn how these findings pave the way for new, more effective Alzheimer's treatments.

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Alzheimer's Gene an Even Bigger Trigger

Until recently, APOE-e4 was thought to be the highest-risk Alzheimer's gene. Then, a newly discovered immune-system gene began getting even more attention. Find out why researchers are excited about its potential to lead them to the door of a better Alzheimer's treatment.

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Genetic Test Predicts Alzheimer's Better

DNA: The PHS genetic test may one day diagnose Alzheimer's before symptoms occur. Learn how looking at genes beyond ApoE4 holds big answers to tough questions in the fight to beat Alzheimer's.

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In the Lab, Alzheimer's Gene Gets Fixed

PROGRESS: ApoE4 is the best known "Alzheimer's Gene". Gladstone Institute scientists successfully changed the gene's structure. This eliminated certain signs of Alzheimer's, restored normal cell function, and improved survival. Learn all about this giant step forward.

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Do Genetics Cause Alzheimer's?

VIDEO:

Dr. Gayatri Devi (Neurologist and author of The Spectrum of Hope: An Optimistic and New Approach to Alzheimer’s) explains the role of genetics in Alzheimer’s and why Alzheimer’s can be slowed or prevented by making lifestyle modifications.

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Can Choline Supplements Beat the Alzheimer's Gene?

GENETIC RESEARCH: Researchers at MIT studying the APOE4 gene are looking at choline supplements and asking whether they can offer protection against Alzheimer's, based on genetic test technology.

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Female Chromosomes Offer Resilience to Alzheimer's

GENETICS & ALZHEIMER'S:

Women's second "X" chromosome provides them with more longevity, and researchers are finding they also have extra protection against Alzheimer's as well, through a special protective protein. Find out more.

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Flu & Pneumonia Vaccine Lower Your Risk of Alzheimer's

PREVENTION: Did you get your flu shot? Doing that and following your doctor's advice to get a vaccination for pneumonia can significantly cut your risk of Alzheimer's, according to exciting research reported at the Alzheimer's Association International Conference. Read on to find out more.

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Why Does Alzheimer's First Attack the Neurons That Hold Our Memories?

Scientists say the neurons responsible for transforming experiences into memories are always the first to go in Alzheimer's. Now they're taking a closer look to try to figure out why, and what to do about it. Learn more.

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Can We Prevent Alzheimer's by Targeting the Gene That Starts It?

Scientists have discovered a specific Alzheimer's gene appears to drive the first appearance of amyloid plaque in the brain. Now they're working on therapies targeting that gene to prevent the disease from developing. Learn more.

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Could One Woman Help Researchers Find A Cure for Alzheimer's?

RESEARCH: Just one woman held the genetic key to unlocking the mystery of how, out of 1,200 members of a South American family, she was the only one to remain free of early-onset Alzheimer's. Find out why.

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How the Alzheimer's Gene Breaks the Brain

GENES: APOE4 is the strongest genetic risk factor of Alzheimer’s, a fact long known by scientists. But until this study at USC, they were unsure how. Find out why they believe they now have the answer.

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Breakthrough Blocks Alzheimer's Gene

GENETIC PROGRESS:

Apoe4 genes increase Alzheimer's risk by 10 times. UT Southwestern researchers succeeded in neutralizing important gene effects. The breakthrough opens doors to developing a pill to lower risk in 50% to 80% of gene carriers.

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Tramiprosate Moves Beyond the "One-Size-Fits-All" Approach to Curing Alzheimer's

Large, significant improvements in genetically-defined Alzheimer's patients were seen in a clinical trial for tramiprosate. Learn about the important potential presented by these Phase-3 trial results.

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One Family's Inherited Alzheimer's

VIDEO + ARTICLE:

Early-onset Alzheimer's is usually inherited, striking ages 30 to 60. Get the details on Early-onset Alzheimer's. See how one family is in a trial to find a breakthrough.

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Alzheimer's Infamous APOE Gene

95% of the time, it takes a combination of genetics, bad environment and unhealthy lifestyle to trigger Alzheimer's. However, one gene called apolipoprotein E (APOE) can make a big difference. Learn more.

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Common Gene May Hold Key to Delaying Alzheimer's 10 Years

Scientists now have a gene variant that seems to push off Alzheimer's by 10 years. Learn how they want to use the way it works to develop a new treatment.

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Cholesterol Triggers Alzheimer's via 3 Copies of Chromose #21

LDL cholesterol is nicknamed "bad cholesterol". It adversely effects cell division. This bad cell division causes human cells to carry a 3rd copy of chromosome #21. Learn why this 3rd copy almost always leads to Alzheimer's.

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